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In male rats, there was increased mineralization of the renal papilla at all exposure concentrations. 0000004737 00000 n
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Hepatocellular adenomas, and adenoma or carcinoma (combined) were increased in male and female mice exposed to 1800 ppm. 0000007876 00000 n
Methyl isobutyl ketone CAS RN: 108-10-1 Storage Conditions. 29 0 obj<>
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We use cookies to help provide and enhance our service and tailor content and ads. MAY FORM EXPLOSIVE PEROXIDES IN AIR. 0000001794 00000 n
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The incidence of chronic progressive nephropathy (CPN) was increased at 1800 ppm and the severity was increased in all exposed groups. 0000001603 00000 n
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AFFECTS CENTRAL NERVOUS SYSTEM, LIVER … Store at Room Temperature. 0000004475 00000 n
Methyl isobutyl ketone is also used in industrial extraction processes, as a solvent for protective coatings and in rare metals extraction and in dewaxing of mineral oils, in drycleaning preparations and in the synthesis of methyl isobutyl carbinol. - [4-Methyl-2-pentanone ; Methylisobutyl ketone, MIBK]:100ppm 410mg/m3 B. xref
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(4) Cancer Risk: No information is available on the carcinogenic effects of methyl isobutyl ketone in humans or animals. Methyl isobutyl ketone (MIBK) is primarily used as a denaturant for rubbing alcohol, as a solvent and in the manufacture of methyl amyl alcohol. h�b```"SVi&~�g`��0p4�9�8��!Y�`�D�%��}�������Lj
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w�c^D�Q The primary targets of MIBK toxicity and carcinogenicity were the kidney in rats and the liver in mice. 0000004813 00000 n
HARMFUL IF INHALED. 0000034054 00000 n
In order to evaluate the potential of MIBK to induce toxic and carcinogenic effects following chronic exposure, groups of 50 male and 50 female F344/N rats and B6C3F1 mice were exposed to MIBK at concentrations of 0, 450, 900, or 1800 ppm by inhalation, 6 h/day, 5 days per week for 2 years. %PDF-1.5
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(4) EPA has classified methyl isobutyl ketone as a Group D, not classifiable as to human carcinogenicity. 0000001344 00000 n
Safety Data Sheet >. %%EOF
in rats and mice exposed to methyl isobutyl ketone by inhalation. Hazards Identification Emergency Overview ----- DANGER! The relationship of these tumors to exposure to MIBK was uncertain. 0000053428 00000 n
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EPA/635/R-03/002 TOXICOLOGICAL REVIEW OF METHYL ISOBUTYL KETONE (CAS No. 0
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Toxicity and carcinogenicity of methyl isobutyl ketone in F344N rats and B6C3F1 mice following 2-year inhalation exposure, https://doi.org/10.1016/j.tox.2007.11.014. Keep container tightly closed in a dry and well-ventilated place. 108-10-1) In Support of Summary Information on the Integrated Risk Information System (IRIS) Methyl isobutyl ketone (MIBK) CASRN 108-10-1 | DTXSID5021889.